| http://purl.uniprot.org/citations/29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29617699 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveThe protein interacting with carboxyl terminus-1 (PICT-1) gene has been implicated as a tumor suppressor gene, and its alterations have been reported in several cancers. This study investigated the association of PICT-1 alterations with endometrial carcinogenesis.MethodsWe analyzed the entire coding region of the PICT-1 gene using polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing to examine PICT-1 mutations in endometrial cancer. Western blotting and immunohistochemical staining were performed to analyze the protein expression and cellular localization of PICT-1 in endometrial cancer cell lines and patient samples.ResultsThe codon 389 polymorphism of PICT-1 increased the risk of endometrial cancer. Interestingly, 2 of 13 endometrial cancers somatically acquired this mutation compared to normal counterparts. Immunohistochemical staining revealed lower levels of PICT-1 in samples from atypical endometrial hyperplasia and endometrial cancer tissues compared to normal endometrial tissues (p < 0.01). This decrease in PICT-1 expression was significantly correlated with histological grade and lymph node metastasis (p < 0.05).ConclusionsThe findings of this study suggest that disruption of PICT-1 protein expression and codon 389 polymorphism can contribute to the pathogenesis or neoplastic progression of endometrial cancer."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.org/dc/terms/identifier | "doi:10.1159/000487189"xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/author | "Yoshimoto M."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/author | "Nishiwaki K."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/author | "Sengoku K."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/author | "Yaginuma Y."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/author | "Tokuda A."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/name | "Oncology"xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/pages | "43-51"xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/title | "Abnormal Expression of PICT-1 and Its Codon 389 Polymorphism Is a Risk Factor for Human Endometrial Cancer."xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/29617699 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29617699 |
| http://purl.uniprot.org/citations/29617699 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29617699 |
| http://purl.uniprot.org/uniprot/#_B4DVK1-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_B4DND9-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_B4E1N4-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
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| http://purl.uniprot.org/uniprot/#_Q53YP0-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_Q9NZM5-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_Q96CS0-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_Q9H7J4-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
| http://purl.uniprot.org/uniprot/#_Q9P0B0-mappedCitation-29617699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29617699 |
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