| http://purl.uniprot.org/citations/29620243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29620243 | http://www.w3.org/2000/01/rdf-schema#comment | "High concentrations of glutamate may mediate neuronal cell apoptosis by increasing intracellular reactive oxygen species (ROS) levels. Peroxiredoxin V (Prx V), a member of the Prx family, serves crucial roles in protecting cells from oxidative stress. The present study investigated the regulatory effect of Prx V on glutamate‑induced effects on viability and apoptosis in HT22 cells. Western blotting was used for protein expression analysis and Annexin V/PI staining and flow cytometry for determination of apoptosis. The results demonstrated that glutamate may ROS‑dependently increase HT22 cell apoptosis and upregulate Prx V protein levels. Furthermore, knockdown of Prx V protein expression with a lentivirus significantly enhanced HT22 cell apoptosis mediated by glutamate, which was reversed by inhibition of ROS with N‑acetyl‑L‑cysteine. Inhibiting the extracellular signal‑regulated kinase (ERK) signaling pathway with PD98059, a specific inhibitor for ERK phosphorylation, markedly decreased glutamate‑induced HT22 cell apoptosis in Prx V knockdown cells, indicating the potential involvement of ERK signaling in glutamate‑induced HT22 cell apoptosis. In addition, an increase in nuclear apoptosis‑inducing factor was observed in Prx V knockdown HT22 cells following glutamate treatment, compared with mock cells, whereas no differences in B‑cell lymphoma‑2 and cleaved‑caspase‑3 protein expression levels were observed between mock and Prx V knockdown cells. The results of the present study indicated that Prx V may have potential as a therapeutic molecular target for glutamate‑induced neuronal cell death and provide novel insight into the role of Prx V in oxidative‑stress induced neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.org/dc/terms/identifier | "doi:10.3892/mmr.2018.8826"xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Lee D.S."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Jin C.H."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Han Y.H."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Kwon T.H."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Jin M.H."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Sun H.N."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Cui Y.D."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Jin Y.Z."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/author | "Shen G.N."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/name | "Mol Med Rep"xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/pages | "7827-7834"xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/title | "Knockdown of peroxiredoxin V increases glutamate‑induced apoptosis in HT22 hippocampal neuron cells."xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/29620243 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29620243 |
| http://purl.uniprot.org/citations/29620243 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29620243 |
| http://purl.uniprot.org/uniprot/#_P99029-mappedCitation-29620243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29620243 |
| http://purl.uniprot.org/uniprot/#_Q3U7H9-mappedCitation-29620243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29620243 |
| http://purl.uniprot.org/uniprot/#_Q9D6X2-mappedCitation-29620243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29620243 |