| http://purl.uniprot.org/citations/29621484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29621484 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysfunction of the neuronal RNA binding protein RBFOX1 has been linked to epilepsy and autism spectrum disorders. Rbfox1 loss in mice leads to neuronal hyper-excitability and seizures, but the physiological basis for this is unknown. We identify the vSNARE protein Vamp1 as a major Rbfox1 target. Vamp1 is strongly downregulated in Rbfox1 Nes-cKO mice due to loss of 3' UTR binding by RBFOX1. Cytoplasmic Rbfox1 stimulates Vamp1 expression in part by blocking microRNA-9. We find that Vamp1 is specifically expressed in inhibitory neurons, and that both Vamp1 knockdown and Rbfox1 loss lead to decreased inhibitory synaptic transmission and E/I imbalance. Re-expression of Vamp1 selectively within interneurons rescues the electrophysiological changes in the Rbfox1 cKO, indicating that Vamp1 loss is a major contributor to the Rbfox1 Nes-cKO phenotype. The regulation of interneuron-specific Vamp1 by Rbfox1 provides a paradigm for broadly expressed RNA-binding proteins performing specialized functions in defined neuronal subtypes."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2018.03.008"xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Lee J.A."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "de la Torre-Ubieta L."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Black D.L."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "O'Dell T.J."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Damianov A."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Martin K.C."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Otis K.O."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Halabi R."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/author | "Vuong C.K."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/pages | "127-141.e7"xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/title | "Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1."xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/29621484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29621484 |
| http://purl.uniprot.org/citations/29621484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29621484 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SUV3-mappedCitation-29621484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29621484 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHB5-mappedCitation-29621484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29621484 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI79-mappedCitation-29621484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29621484 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VK79-mappedCitation-29621484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29621484 |