| http://purl.uniprot.org/citations/29624776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29624776 | http://www.w3.org/2000/01/rdf-schema#comment | "Transient receptor potential canonical channel 3 (TRPC3) proteins function as non-voltage-gated Ca2+ -permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression and airway hyperresponsiveness and remodeling in ovalbumin-induced asthmatic Kunming mice. Mice were sensitized and challenged by ovalbumin to establish asthmatic model. Hematoxylin-eosin staining, hydroxyproline assay, and isometric tracheal ring force measurement were used to evaluate airway remodeling and hyperresponsiveness in asthmatic mice. Western blot was performed to detect the expression of TRPC3 proteins. MTT assay was used to measure the proliferation of airway smooth muscle cells. TRPC3 protein expression increased in airway smooth muscle of asthmatic mice. GdCl3 , a nonspecific TRPC blocker, attenuated the contractile force of airway smooth muscle. Fetal bovine serum stimulated airway smooth muscle cells proliferation and augmented TRPC3 protein expression. Both TRPC3 blockade by GdCl3 or specific TRPC3 antibodies and gene silencing by siRNA inhibited the proliferation of airway smooth muscle cells. In contrast, the current drugs treatment for asthma such as Dexamethasone and Aminophylline had no effects on TRPC3 protein overexpression. Therefore, TRPC3 protein overexpression may be involved in airway smooth muscle hyperresponsiveness and remodeling in asthmatic mice, providing evidence for a new direction of asthma pathogenesis research and a new target for drug intervention."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.10970"xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/author | "Wang J.L."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/author | "Xiao J.H."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/author | "Xu B.M."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/pages | "1021-1029"xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/title | "TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin-induced hyperresponsiveness and remodeling."xsd:string |
| http://purl.uniprot.org/citations/29624776 | http://purl.uniprot.org/core/volume | "42"xsd:string |
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