| http://purl.uniprot.org/citations/29632046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29632046 | http://www.w3.org/2000/01/rdf-schema#comment | "The Endoplasmic reticulum aminopeptidase I (ERAP1) trims peptides to their optimal size for binding to Major Histocompatibility Complex class I proteins. The natural polymorphism of this enzyme is associated with ankylosing spondylitis (AS) in epistasis with the major risk factor for this disease, HLA-B*27, suggesting a direct relationship between AS and HLA-B*27-bound peptides. Three polymorphisms that affect peptide trimming protect from AS: K528R, D575N/R725Q, and Q730E. We characterized and ranked the effects of each mutation, and their various combinations, by quantitative comparisons of the HLA-B*27 peptidomes from cells expressing distinct ERAP1 variants. Five features were examined: peptide length, N-terminal flanking residues, N-terminal residues of the natural ligands, internal sequences and affinity for B*27:05. Polymorphism at residue 528 showed the largest influence, affecting all five features regardless of peptide length. D575N/R725Q showed a much smaller effect. Yet, when co-occurring with K528R, it further decreased ERAP1 activity. Polymorphism at residue 730 showed a significant influence on peptide length, because of distinct effects on trimming of nonamers compared with longer peptides. Accordingly, multiple features were affected by the Q730E mutation in a length-dependent way. The alterations induced in the B*27:05 peptidome by natural ERAP1 variants with different K528R/Q730E combinations reflected separate and additive effects of both mutations. Thus, the influence of ERAP1 on HLA-B*27 is very diverse at the population level, because of the multiplicity and complexity of ERAP1 variants, and to the distinct effects of their co-occurring polymorphisms, leading to significant modulation of disease risk among HLA-B*27-positive individuals."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.ra117.000565"xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Admon A."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Lopez de Castro J.A."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Barnea E."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Alvarez-Navarro C."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Martin-Esteban A."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/author | "Sanz-Bravo A."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/pages | "1308-1323"xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/title | "Ranking the Contribution of Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphisms to Shaping the HLA-B*27 Peptidome."xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/29632046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29632046 |
| http://purl.uniprot.org/citations/29632046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29632046 |
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