Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/29650297http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29650297http://www.w3.org/2000/01/rdf-schema#comment"

Background and aims

Laboratory studies on human adipose tissue and differentiated adipocytes indicate that natriuretic peptides (NPs) affect lipid metabolism and plasma cholesterol. Few previous clinical studies in non-elderly populations found associations between NPs in the physiological range and cholesterol.

Aim

evaluate the association between NT-proBNP and lipid profile in very elderly hospitalized patients characterized by a wide range of NT-proBNP levels.

Methods and results

Cross-sectional study on 288 very elderly patients hospitalized for medical conditions, in which increased NT-proBNP levels are very common. NT-proBNP, total cholesterol (TC), HDL cholesterol (HDLc) and triglycerides were collected just few days before discharge. Patients taking lipid-lowering drugs and patients with an admission diagnosis of acute heart failure were excluded. Calculated LDL-cholesterol (LDLc) was used for the analyses. Mean age: 87.7 ± 6.2 years; female prevalence (57.3%). Median NT-proBNP: 2949 (1005-7335) pg/ml; mean TC: 145.1 ± 40.3 mg/dl; mean HDLc: 38.4 ± 18.6 mg/dl; median triglycerides: 100 (75-129) mg/dl; mean LDLc: 84.0 ± 29.5 mg/dl. We found negative correlations between NT-proBNP and both TC and LDLc (Rho = -0.157; p = 0.008 and Rho = -0.166; p = 0.005, respectively), while no correlations emerged between NT-proBNP and HDLc (Rho = -0.065; p = 0.275) or triglycerides (Rho = -0.009; p = 0.874). These associations were confirmed considering NT-proBNP tertiles. The inverse association between NT-proBNP and LDLc was maintained even after adjusting for confounding factors.

Conclusion

Our real-life clinical study supports the hypothesis that NPs play a role on cholesterol metabolism, given the association found between LDLc and NT-proBNP even in very elderly patients where NT-proBNP values are often in the pathological range."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.org/dc/terms/identifier"doi:10.1016/j.numecd.2018.02.013"xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Bordicchia M."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Sarzani R."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Bernardi B."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Giordano P."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Landi L."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Giulietti F."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Spannella F."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Bordoni V."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Borioni E."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Cocci G."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Lombardi F.E."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/author"Rosettani G."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/date"2018"xsd:gYear
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/name"Nutr Metab Cardiovasc Dis"xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/pages"629-635"xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/title"N-terminal pro B-Type natriuretic peptide is inversely correlated with low density lipoprotein cholesterol in the very elderly."xsd:string
http://purl.uniprot.org/citations/29650297http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/29650297http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/29650297
http://purl.uniprot.org/citations/29650297http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/29650297
http://purl.uniprot.org/uniprot/#_P16860-mappedCitation-29650297http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/29650297
http://purl.uniprot.org/uniprot/P16860http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/29650297