| http://purl.uniprot.org/citations/29651144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29651144 | http://www.w3.org/2000/01/rdf-schema#comment | "Cisplatin-induced acute kidney injury (AKI) has been recognized as one of cisplatin's serious side effects, limiting its use in cancer therapy. Sirtuin 1 (SIRT1) and SIRT3 play protective roles against cisplatin-induced kidney injury. However, the role of SIRT7 in cisplatin-induced kidney injury is not yet known. In this study, we found that Sirt7 knockout (KO) mice were resistant to cisplatin-induced AKI. Furthermore, our studies identified that loss of SIRT7 decreases the expression of tumor necrosis factor-α (TNF-α) by regulating the nuclear expression of the transcription factor nuclear factor kappa B. It has been reported that cisplatin-induced nephrotoxicity is mediated by TNF-α. Our results indicate that SIRT7 plays an important role in cisplatin-induced AKI and suggest the possibility of SIRT7 as a novel therapeutic target for cisplatin-induced nephrotoxicity."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-018-24257-7"xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Braun T."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Nakagawa T."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Sato Y."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Yoshizawa T."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Adachi M."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Mukoyama M."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Komohara Y."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Kuwabara T."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Ianni A."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Kakizoe Y."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Miyasato Y."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/author | "Miyasato Y.'"xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/pages | "5927"xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/title | "Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response."xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/29651144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29651144 |
| http://purl.uniprot.org/citations/29651144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29651144 |
| http://purl.uniprot.org/uniprot/#_A2ABY6-mappedCitation-29651144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29651144 |
| http://purl.uniprot.org/uniprot/#_A2ABY8-mappedCitation-29651144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29651144 |