| http://purl.uniprot.org/citations/29656893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29656893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29656893 | http://www.w3.org/2000/01/rdf-schema#comment | "Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining proximity labeling with quantitative mass spectrometry, we generated high-resolution interaction neighborhood maps of the endogenously expressed DNA repair factors 53BP1, BRCA1, and MDC1. Our spatially resolved interaction maps reveal rich network intricacies, identify shared and bait-specific interaction modules, and implicate previously concealed regulators in this process. We identified a novel vertebrate-specific protein complex, shieldin, comprising REV7 plus three previously uncharacterized proteins, RINN1 (CTC-534A2.2), RINN2 (FAM35A), and RINN3 (C20ORF196). Recruitment of shieldin to DSBs, via the ATM-RNF8-RNF168-53BP1-RIF1 axis, promotes NHEJ-dependent repair of intrachromosomal breaks, immunoglobulin class-switch recombination (CSR), and fusion of unprotected telomeres. Shieldin functions as a downstream effector of 53BP1-RIF1 in restraining DNA end resection and in sensitizing BRCA1-deficient cells to PARP inhibitors. These findings have implications for understanding cancer-associated PARPi resistance and the evolution of antibody CSR in higher vertebrates."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2018.03.050"xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2018.03.050"xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Gupta R."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Gupta R."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Narita T."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Narita T."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Typas D."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Typas D."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Kremer M."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Kremer M."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Lammers M."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Lammers M."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Maskey E."xsd:string |
| http://purl.uniprot.org/citations/29656893 | http://purl.uniprot.org/core/author | "Maskey E."xsd:string |