| http://purl.uniprot.org/citations/29663519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29663519 | http://www.w3.org/2000/01/rdf-schema#comment | "Background and aimAlcohol dehydrogenases (ADHs) 1 and 3 are responsible for systemic alcohol metabolism. The current study investigated the contribution of liver ADH1 and ADH3 to the metabolic pharmacokinetics of chronic alcohol consumption (CAC).MethodsThe 9-week-old male mice of different ADH genotypes (wild-type [WT], Adh1-/- , and Adh3-/- ) were administered with 10% ethanol solution for 1 month, followed by acute ethanol administration (4.0 g/kg). The alcohol elimination rate (AER), area under the blood alcohol concentration curve (AUC), and the maximum blood alcohol concentration (Cmax ) were calculated. The liver content, activity, and mRNA levels of ADH were evaluated.ResultsChronic alcohol consumption increased the AER and reduced the AUC in all ADH genotypes. The increased ADH1 content was correlated with AER in WT mice but not in the Adh3-/- mice. Similarly, the increased ADH3 content was also correlated with AER in both WT and Adh1-/- mice. The Cmax was significantly higher in Adh3-/- control mice than in WT control mice. It decreased in the Adh1-/- mice by CAC along with an increase in the ADH3 content.ConclusionsAlcohol dehydrogenases 1 and 3 would accomplish the pharmacokinetic adaptation to CAC in the early period. ADH1 contributes to the metabolic pharmacokinetics of CAC with a decrease in AUC in conjunction with an increase of AER by increasing the enzyme content in the presence of ADH3. ADH3 also contributes to a decrease in AUC in conjunction with not only an increase in AER but also a decrease in Cmax by increasing the enzyme content."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.org/dc/terms/identifier | "doi:10.1111/jgh.14260"xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Maruyama M."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Ohno Y."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Okuda T."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Katsuyama M."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Igarashi T."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Haseba T."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/author | "Akimoto T."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/name | "J Gastroenterol Hepatol"xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/pages | "1912-1919"xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/title | "Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice."xsd:string |
| http://purl.uniprot.org/citations/29663519 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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