| http://purl.uniprot.org/citations/29664006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29664006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29664006 | http://www.w3.org/2000/01/rdf-schema#comment | "How multicellular organisms respond to and are impacted by severe hypothermic stress is largely unknown. From C. elegans screens for mutants abnormally responding to cold-warming stimuli, we identify a molecular genetic pathway comprising ISY-1, a conserved uncharacterized protein, and ZIP-10, a bZIP-type transcription factor. ISY-1 gatekeeps the ZIP-10 transcriptional program by regulating the microRNA mir-60. Downstream of ISY-1 and mir-60, zip-10 levels rapidly and specifically increase upon transient cold-warming exposure. Prolonged zip-10 up-regulation induces several protease-encoding genes and promotes stress-induced organismic death, or phenoptosis, of C. elegans. zip-10 deficiency confers enhanced resistance to prolonged cold-warming stress, more prominently in adults than larvae. We conclude that the ZIP-10 genetic program mediates cold-warming response and may have evolved to promote wild-population kin selection under resource-limiting and thermal stress conditions."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.35037"xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.35037"xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Luo S."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Long Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Long Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Dang Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Dang Y."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Ma D.K."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Ma D.K."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Owen A."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/author | "Owen A."xsd:string |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29664006 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |