| http://purl.uniprot.org/citations/29670628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29670628 | http://www.w3.org/2000/01/rdf-schema#comment | "The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment. Here, we report that GPR18 is also functionally expressed in conventional CD8αβ T cells. When the receptor is lacking, mice develop fewer CD8+ KLRG1+ Granzyme B+ effector-memory cells. Bone marrow chimera studies show that the GPR18 requirement is CD8 T cell intrinsic. GPR18 is not required for T-bet expression in KLRG1+ CD8 T cells. Gene transduction experiments confirm the functional activity of GPR18 in CD8 T cells. In summary, we describe a novel GPCR requirement for establishment or maintenance of the CD8 KLRG1+ effector-memory T cell compartment. These findings have implications for methods to augment CD8 effector cell numbers."xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.00660"xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/author | "Sumida H."xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/pages | "660"xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/title | "G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment."xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29670628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29670628 |
| http://purl.uniprot.org/citations/29670628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29670628 |
| http://purl.uniprot.org/uniprot/#_Q8K1Z6-mappedCitation-29670628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29670628 |
| http://purl.uniprot.org/uniprot/Q8K1Z6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29670628 |