| http://purl.uniprot.org/citations/29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29679094 | http://www.w3.org/2000/01/rdf-schema#comment | "Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the pro-mitotic effect of physical activity. Here, we examine precursor cells in the adult brain of mice lacking angiotensin-converting enzyme (ACE) 2, and explore the effect of an acute running stimulus on neurogenesis. ACE2 metabolizes Ang II to Ang-(1-7) and is essential for the intestinal uptake of tryptophan (Trp), the 5-HT precursor. In ACE2-deficient mice, we observed a decrease in brain 5-HT levels and no increase in the number of BrdU-positive cells following exercise. Targeting the Ang II/AT1 axis by blocking the receptor, or experimentally increasing Trp/5-HT levels in the brain of ACE2-deficient mice, did not rescue the running-induced effect. Furthermore, mice lacking the Ang-(1-7) receptor, Mas, presented a normal neurogenic response to exercise. Our results identify ACE2 as a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for 5-HT metabolism."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-018-2815-y"xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Bader M."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Alenina N."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Santos R.A.S."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Todiras M."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Matthes S."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Klempin F."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Mosienko V."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/author | "Villela D.C."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/name | "Cell Mol Life Sci"xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/pages | "3625-3634"xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/title | "Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response."xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/29679094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29679094 |
| http://purl.uniprot.org/citations/29679094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29679094 |
| http://purl.uniprot.org/uniprot/#_E0CYD1-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |
| http://purl.uniprot.org/uniprot/#_Q0VB49-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |
| http://purl.uniprot.org/uniprot/#_E0CX40-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |
| http://purl.uniprot.org/uniprot/#_E0CX57-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |
| http://purl.uniprot.org/uniprot/#_E0CX70-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |
| http://purl.uniprot.org/uniprot/#_C7ECU2-mappedCitation-29679094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29679094 |