| http://purl.uniprot.org/citations/29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29681474 | http://www.w3.org/2000/01/rdf-schema#comment | "The reward system is a collection of circuits that reinforce behaviors necessary for survival [1, 2]. Given the importance of reproduction for survival, actions that promote successful mating induce pleasurable feeling and are positively reinforced [3, 4]. This principle is conserved in Drosophila, where successful copulation is naturally rewarding to male flies, induces long-term appetitive memories [5], increases brain levels of neuropeptide F (NPF, the fly homolog of neuropeptide Y), and prevents ethanol, known otherwise as rewarding to flies [6, 7], from being rewarding [5]. It is not clear which of the multiple sensory and motor responses performed during mating induces perception of reward. Sexual interactions with female flies that do not reach copulation are not sufficient to reduce ethanol consumption [5], suggesting that only successful mating encounters are rewarding. Here, we uncoupled the initial steps of mating from its final steps and tested the ability of ejaculation to mimic the rewarding value of full copulation. We induced ejaculation by activating neurons that express the neuropeptide corazonin (CRZ) [8] and subsequently measured different aspects of reward. We show that activating Crz-expressing neurons is rewarding to male flies, as they choose to reside in a zone that triggers optogenetic stimulation of Crz neurons and display conditioned preference for an odor paired with the activation. Reminiscent of successful mating, repeated activation of Crz neurons increases npf levels and reduces ethanol consumption. Our results demonstrate that ejaculation stimulated by Crz/Crz-receptor signaling serves as an essential part of the mating reward mechanism in Drosophila. VIDEO ABSTRACT."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2018.03.039"xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Shao L."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Shmueli A."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Shohat-Ophir G."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Bentzur A."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Ben-Shaanan S."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Tordjman L."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Zak H."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/author | "Zer-Krispil S."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/pages | "1445-1452.e3"xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/title | "Ejaculation Induced by the Activation of Crz Neurons Is Rewarding to Drosophila Males."xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/29681474 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29681474 |
| http://purl.uniprot.org/citations/29681474 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29681474 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG37-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |
| http://purl.uniprot.org/uniprot/#_M9PF00-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |
| http://purl.uniprot.org/uniprot/#_Q9VTW7-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |
| http://purl.uniprot.org/uniprot/#_Q26377-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |
| http://purl.uniprot.org/uniprot/#_Q8ITC8-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |
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| http://purl.uniprot.org/uniprot/#_Q9VET0-mappedCitation-29681474 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29681474 |