| http://purl.uniprot.org/citations/29689246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29689246 | http://www.w3.org/2000/01/rdf-schema#comment | "More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause-and-effect relationship, and designated as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram-negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogene JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL. Here we report that BIA-ALCL cell lines and anaplastic lymphoma cells in clinical specimens produce IL-13, the signature cytokine of allergic inflammation. Supporting the link of BIA-ALCL to allergic inflammation, lymphoma cells were often surrounded by eosinophils and mast cells, features typically absent in systemic ALCL. Because of the link of IL-13 to allergy, we looked for IgE and found it decorating the surface of mast cells and antigen-presenting follicular dendritic cells in capsules and lymph nodes infiltrated by anaplastic lymphoma cells, but not uninvolved capsules. Plasma cells within capsules and regional lymph nodes were identified as a possible source of IgE. Together, these findings suggest the hypothesis that an amplified immune response with features of a chronic allergic reaction in a susceptible patient underlies the pathogenesis of BIA-ALCL."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humpath.2018.04.007"xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Morgan J."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Epstein A.L."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Medeiros L.J."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Bacchi C.E."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Kadin M.E."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Miranda R.N."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Adams W.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Clemens M.W."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Goes J.C.S."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Hubbard B.A."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/author | "Sieber D."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/name | "Hum Pathol"xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/pages | "54-62"xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/title | "IL-13 is produced by tumor cells in breast implant-associated anaplastic large cell lymphoma: implications for pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/29689246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29689246 |
| http://purl.uniprot.org/citations/29689246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29689246 |
| http://purl.uniprot.org/uniprot/#_Q4VB50-mappedCitation-29689246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29689246 |
| http://purl.uniprot.org/uniprot/#_Q4VB51-mappedCitation-29689246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29689246 |
| http://purl.uniprot.org/uniprot/#_Q4VB53-mappedCitation-29689246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29689246 |