| http://purl.uniprot.org/citations/29694894 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29694894 | http://www.w3.org/2000/01/rdf-schema#comment | "Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed an unbiased screening and identified the miR-200 family as the most relevant miRNAs downregulated by PKCζ deficiency. The regulation of the intracellular levels of miR-200 by PKCζ is post-transcriptional and involves their secretion in extracellular vesicles. Here, we identified ADAR2 as a direct substrate of PKCζ in CRC cells. Phosphorylation of ADAR2 regulates its editing activity, which is required to maintain miR-200 steady-state levels, suggesting that the PKCζ/ADAR2 axis regulates miR-200 secretion through RNA editing. Loss of this axis results in epithelial-to-mesenchymal transition (EMT) and increased liver metastases, which can be inhibited in vivo by blocking miR-200 release. Therefore, the PKCζ/ADAR2 axis is a critical regulator of CRC metastases through modulation of miR-200 levels."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2018.03.118"xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Nakanishi Y."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Campos A."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Duran A."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Garcia-Arranz M."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Caceres J.F."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Llado V."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Garcia-Olmo D."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Garcia-Olmo D.C."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Kasashima H."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Reina-Campos M."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Shelton P.M."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/author | "Olmedillas-Lopez S."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/pages | "1178-1191"xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/title | "The Secretion of miR-200s by a PKCzeta/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer."xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/29694894 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29694894 |
| http://purl.uniprot.org/citations/29694894 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29694894 |