| http://purl.uniprot.org/citations/29721855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29721855 | http://www.w3.org/2000/01/rdf-schema#comment | "Amyloid beta-peptide (Aβ), the neurotoxic component of senile plaques in Alzheimer's disease (AD) brains, is known to trigger cell cycle reentry in post-mitotic neurons followed by apoptosis. However, the underlying mechanisms remain unclear. Recently, we have reported that Aβs stimulate the expression of inhibitor of differentiation-1 (Id1) to induce sonic hedgehog (SHH) (Hung et al., Mol Neurobiol 53(2):793-809, 2016), and both are mitogens capable of triggering cell cycle progression. In this work, we tested the hypothesis that Aβ-induced Id1 and SHH contribute to cell cycle reentry leading to apoptosis in neurons. We found that Aβ triggered cell cycle progression in the post-mitotic neurons, as indicated by the increased expression of two G1-phase markers including cyclin D1 and phosphorylated retinoblastoma protein (pRb), two G2-phase markers such as proliferating cell nuclear antigen (PCNA) and incorporation of 5-bromo-2'-deoxyuridine (BrdU) into newly synthesized DNA, as well as the mitotic marker histone H3 phosphorylated at Ser-10. As expected, Aβ also enhanced caspase-3 cleavage in the cortical neurons. Id1 siRNA, the neutralization antibody against SHH (SHH-Ab), and the cyclin-dependent kinase (CDK)-4/6 inhibitor PD0332991 all attenuated, in part or in full, the Aβ-induced expression of these cell cycle markers. Indeed, exogenous recombinant Id1 protein and the biologically active N-terminal fragment of SHH (SHH-N) were both sufficient to enhance the expression of cell cycle markers independent of Aβ. Taken together, our results revealed the critical roles of Id1 and SHH mediating Aβ-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons, at least in vitro."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-018-1098-5"xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Chang S.H."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Hwang W.C."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Huang C.T."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Yang D.I."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/author | "Chao A.C."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/pages | "465-489"xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/title | "Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons."xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/29721855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29721855 |
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