| http://purl.uniprot.org/citations/29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29730307 | http://www.w3.org/2000/01/rdf-schema#comment | "The highly pathogenic avian influenza (HPAI) A/H5N1 virus hijacks host cellular machinery to complete its life cycle; identification of the host factors involved in viral replication may facilitate antiviral drug development. Here, we first characterize a metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), and showed that it plays a crucial role in H5N1 viral replication. We found that H5N1 infection upregulated NDRG1 mRNA and protein expression. Overexpression of NDRG1 released approximately 4-fold more virions compared to the control group, whereas knockdown of NDRG1 resulted in a drop in viral RNA and protein production. Further investigation revealed that NDRG1 facilitated HPAI A/H5N1 viral replication by suppressing the canonical NF-κB signaling pathway. Furthermore, our results also showed that the NDRG1 mRNA level was mainly stimulated by M1 and PB1 viral proteins. Overall, our results suggest that NDRG1 plays a positive role in HPAI replication by suppressing the canonical NF-κB signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virusres.2018.05.001"xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Shi Q."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Ma G."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Su W."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/author | "Xing C."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/name | "Virus Res"xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/pages | "22-28"xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/title | "N-myc downstream-regulated gene 1 facilitates influenza A virus replication by suppressing canonical NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://purl.uniprot.org/core/volume | "252"xsd:string |
| http://purl.uniprot.org/citations/29730307 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29730307 |
| http://purl.uniprot.org/citations/29730307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29730307 |
| http://purl.uniprot.org/uniprot/#_A0A6Q8PHF2-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_B3KU62-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_B7Z4H0-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_B7Z505-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_B3KWB2-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_B7Z5Z7-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |
| http://purl.uniprot.org/uniprot/#_Q53EU7-mappedCitation-29730307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29730307 |