| http://purl.uniprot.org/citations/29730647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29730647 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to explore the effect of MED27 on the expression of epithelial-mesenchymal transition (EMT)-related proteins and β-catenin in adrenal cortical carcinoma (ACC). The functional mechanism of MED27 on ACC processes was also explored. The expression of MED27 was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). siRNA was utilized to knockdown the expression of MED27. CCK8 assays were performed to evaluate SW-13 cell proliferation. Transwell assays were performed to assess the invasion ability, and wound healing assays were utilized to detect migration. A tumor xenograft mouse model was established to investigate the impact of silencing MED27 on tumor growth and metastasis. MED27 was highly expressed in ACC tissues and cells. Down-regulation of MED27 induced ACC cell apoptosis, and significantly attenuated ACC cell proliferation, invasion and metastasis in vivo and in vitro. MED27 knockdown regulated the expression of EMT-related proteins and Wnt/β-catenin signaling pathway-related proteins. Our study investigated the function and mechanism of MED27 and validated that MED27 plays a negative role in ACC occurrence and progression and could be utilized as a new therapeutic target in ACC prevention and treatment."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.org/dc/terms/identifier | "doi:10.1515/hsz-2017-0304"xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "Sun F."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/author | "Dai J."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/name | "Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/pages | "593-602"xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/title | "Silencing of MED27 inhibits adrenal cortical carcinogenesis by targeting the Wnt/beta-catenin signaling pathway and the epithelial-mesenchymal transition process."xsd:string |
| http://purl.uniprot.org/citations/29730647 | http://purl.uniprot.org/core/volume | "399"xsd:string |
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