| http://purl.uniprot.org/citations/29730765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29730765 | http://www.w3.org/2000/01/rdf-schema#comment | "Calsenilin is a calcium ion (Ca2+)-binding protein involved in regulating the intracellular concentration of Ca2+, a second messenger that controls multiple cellular signaling pathways. The ryanodine receptor (RyR) amplifies Ca2+ signals entering the cytoplasm by releasing Ca2+ from endoplasmic reticulum (ER) stores, a process termed calcium-induced calcium release (CICR). Here, we describe a novel mechanism, in which calsenilin controls the activity of neuronal RyRs. We show calsenilin co-localized with RyR2 and 3 in the ER of mouse hippocampal and cortical neurons using immunocytochemistry. The underlying protein-protein interaction between calsenilin and the RyR was determined in mouse central nervous system (CNS) neurons using immunoprecipitation studies. The functional relevance of this interaction was assayed with single-channel electrophysiology. At low physiological Ca2+ concentrations, calsenilin binding to the cytoplasmic face of neuronal RyRs decreased the RyR's open probability, while calsenilin increased the open probability at high physiological Ca2+ concentrations. This novel molecular mechanism was studied further at the cellular level, where faster release kinetics of caffeine-induced Ca2+ release were measured in SH-SY5Y neuroblastoma cells overexpressing calsenilin. The interaction between calsenilin and neuronal RyRs reveals a new regulatory mechanism and possibly a novel pharmacological target for the control of Ca2+ release from intracellular stores."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-018-1080-2"xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/author | "Koulen P."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/author | "Grillo S.L."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/author | "Grillo M.A."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/author | "Gerdes B.C."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/author | "Kraus J.G."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/date | "2019"xsd:gYear |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/pages | "525-534"xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/title | "Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin."xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/29730765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29730765 |
| http://purl.uniprot.org/citations/29730765 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29730765 |
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