| http://purl.uniprot.org/citations/29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29733411 | http://www.w3.org/2000/01/rdf-schema#comment | "The GTPase EF-Tu in ternary complex with GTP and aminoacyl-tRNA (aa-tRNA) promotes rapid and accurate delivery of cognate aa-tRNAs to the ribosomal A site. Here we used cryo-EM to study the molecular origins of the accuracy of ribosome-aided recognition of a cognate ternary complex and the accuracy-amplifying role of the monitoring bases A1492, A1493 and G530 of the 16S rRNA. We used the GTPase-deficient EF-Tu variant H84A with native GTP, rather than non-cleavable GTP analogues, to trap a near-cognate ternary complex in high-resolution ribosomal complexes of varying codon-recognition accuracy. We found that ribosome complexes trapped by GTPase-deficicent ternary complex due to the presence of EF-TuH84A or non-cleavable GTP analogues have very similar structures. We further discuss speed and accuracy of initial aa-tRNA selection in terms of conformational changes of aa-tRNA and stepwise activation of the monitoring bases at the decoding center of the ribosome."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gky346"xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Frank J."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Fislage M."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Sanyal S."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Ehrenberg M."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Mandava C.S."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/author | "Brown Z.P."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/pages | "5861-5874"xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/title | "Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A."xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/29733411 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29733411 |
| http://purl.uniprot.org/citations/29733411 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29733411 |
| http://purl.uniprot.org/uniprot/#_P0ADZ0-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
| http://purl.uniprot.org/uniprot/#_P0ADZ4-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
| http://purl.uniprot.org/uniprot/#_P0AG44-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
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| http://purl.uniprot.org/uniprot/#_P0AG51-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
| http://purl.uniprot.org/uniprot/#_P0AG55-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
| http://purl.uniprot.org/uniprot/#_P0AG59-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |
| http://purl.uniprot.org/uniprot/#_P0AG63-mappedCitation-29733411 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29733411 |