| http://purl.uniprot.org/citations/29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29734363 | http://www.w3.org/2000/01/rdf-schema#comment | "A pituitary adenylate cyclase-activating polypeptide (PACAP)-specific receptor, PAC1R, is coupled with multiple signal transduction pathways including stimulation of adenylate cyclase, phospholipase C and extracellular-signal regulated kinase (ERK)1/2. PAC1R has been shown to exert its long-lasting and potent signals via β-arrestin1 and β-arrestin2. However, the precise roles of the two β-arrestin isoforms in PACAP-PAC1R signaling remain unclear. Here we examined the interaction between the two β-arrestin isoforms and PAC1R, β-arrestin-dependent PAC1R subcellular localization and ERK1/2 activation. Upon PACAP stimulation, although PAC1R similarly interacted with β-arrestin1 and β-arrestin2 in HEK293T cells, the complex of PAC1R and β-arrestin2 was translocated from the cell surface into cytosol, but that of β-arrestin1 remained in the cell surface regions in HeLa cells and mouse primary cultured neurons. Silencing of β-arrestin2 blocked PACAP-induced PAC1R internalization and ERK1/2 phosphorylation, but silencing of β-arrestin1 increased ERK1/2 phosphorylation. These results show that β-arrestin1 and β-arrestin2 exert differential actions on PAC1R internalization and PAC1R-dependent ERK1/2 activation, and suggest that the two β-arrestin isoforms may be involved in fine and precise tuning of the PAC1R signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0196946"xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Moriguchi K."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Hashimoto H."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Nakazawa T."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Shintani N."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Shintani Y."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Ago Y."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Kasai A."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Hayata-Takano A."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/author | "Seiriki K."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/pages | "e0196946"xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/title | "beta-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking."xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/29734363 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29734363 |
| http://purl.uniprot.org/citations/29734363 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29734363 |
| http://purl.uniprot.org/uniprot/#_A0A090N8F8-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |
| http://purl.uniprot.org/uniprot/#_A8K103-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |
| http://purl.uniprot.org/uniprot/#_A0A994J7E9-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |
| http://purl.uniprot.org/uniprot/#_B7Z1Q3-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |
| http://purl.uniprot.org/uniprot/#_A8K4I6-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |
| http://purl.uniprot.org/uniprot/#_P41586-mappedCitation-29734363 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29734363 |