| http://purl.uniprot.org/citations/29736013 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29736013 | http://www.w3.org/2000/01/rdf-schema#comment | "The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a property shared with its catalytically inactive Y-chromosome paralog, UTY (or KDM6C). In keeping with this, we demonstrate concomitant loss/mutation of KDM6A (UTX) and UTY in multiple human cancers. Mechanistically, global genomic profiling showed only minor changes in H3K27me3 but significant and bidirectional alterations in H3K27ac and chromatin accessibility; a predominant loss of H3K4me1 modifications; alterations in ETS and GATA-factor binding; and altered gene expression after Utx loss. By integrating proteomic and genomic analyses, we link these changes to UTX regulation of ATP-dependent chromatin remodeling, coordination of the COMPASS complex and enhanced pioneering activity of ETS factors during evolution to AML. Collectively, our findings identify a dual role for UTX in suppressing acute myeloid leukemia via repression of oncogenic ETS and upregulation of tumor-suppressive GATA programs."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41588-018-0114-z"xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Cooper J."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Kondo S."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Knights A.J."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Varela I."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Choudhary J.S."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Pardo M."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Adams D."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Northcott P.A."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Park N."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Dovey O."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Vassiliou G.S."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Gottgens B."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Huntly B.J.P."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Bullinger L."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Yun H."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Iyer V."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "De Braekeleer E."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Garyfallos D.A."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Tzelepis K."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Mazan M."xsd:string |
| http://purl.uniprot.org/citations/29736013 | http://purl.uniprot.org/core/author | "Dudek M."xsd:string |