| http://purl.uniprot.org/citations/29736031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29736031 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells. Nup210-deficient CD4+ T lymphocytes develop normally but fail to survive in the periphery. The decreased survival results from both an impaired ability to transmit tonic T cell receptor (TCR) signals and increased levels of Fas, which sensitize Nup210-/- naïve CD4+ T cells to Fas-mediated cell death. Mechanistically, Nup210 regulates these processes by modulating the expression of Cav2 (encoding Caveolin-2) and Jun at the nuclear periphery. Whereas the TCR-dependent and CD4+ T cell-specific upregulation of Cav2 is critical for proximal TCR signaling, cJun expression is required for STAT3-dependent repression of Fas. Our results uncover an unexpected role for Nup210 as a cell-intrinsic regulator of TCR signaling and T cell homeostasis and expose NPCs as key players in the adaptive immune system."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-018-0103-5"xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Sakuma S."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "D'Angelo M.A."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Raices M."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Carrette F."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Bradley L.M."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Borlido J."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/author | "Tinoco R."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/pages | "594-605"xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/title | "Nuclear pore complex-mediated modulation of TCR signaling is required for naive CD4+ T cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/29736031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29736031 |
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