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http://purl.uniprot.org/citations/29737871http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29737871http://www.w3.org/2000/01/rdf-schema#comment"

Background

Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice.

Objective

The aim of this study was to evaluate usefulness of various biomarkers of myocardial fibrosis and hypertrophy in HCM.

Methods

Levels of biomarkers: soluble ST2 (sST2), galectin-3 (Gal-3), growth differentiation factor-15 (GDF-15), NT-proBNP and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis.

Results

We observed positive correlations among sST2 levels and left ventricular mass (LVM) (r = 0.32, p = 0.012), LV mass indexed for the body surface area (LVMI) (r = 0.27, p = 0.036) and maximal wall thickness (MWT) (r = 0.31, p = 0.015). No correlation was found between Gal-3 and GDF-15 levels and hypertrophy and fibrosis parameters. We observed positive correlations among hs-cTnT levels and LVM (r = 0.58, p < 0.0001), LVMI (r = 0.48, p = 0.0001), MWT (r = 0.31, p = 0.015) and late gadolinium enhancement (LGE) mass (r = 0.37, p = 0.003). There were positive correlations between NT-proBNP levels and LVM (r = 0.33, p = 0.01), LVMI (r = 0.41, p = 0.001), MWT (r = 0.42, p < 0.001) and LGE mass (r = 0.44, p < 0.001).

Conclusions

Although no correlation between sST2 levels and myocardial fibrosis was found, sST2 may provide some additional information about hypertrophy extension. NT-proBNP and hs-cTnT are useful biomarkers in assessment of hypertrophy and fibrosis in HCM."xsd:string
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http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Marczak M."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Wrobel A."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Grzybowski J."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Lutynska A."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Spiewak M."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Kubik A."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/author"Gawor M."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/date"2018"xsd:gYear
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http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/pages"676-682"xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/title"Circulating biomarkers of hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy assessed by cardiac magnetic resonance."xsd:string
http://purl.uniprot.org/citations/29737871http://purl.uniprot.org/core/volume"23"xsd:string
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