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http://purl.uniprot.org/citations/29745082http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29745082http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To explore the correlation of the expression levels of phosphate and tension homology deleted on chromosome ten (PTEN) and p53 of glioblastoma multiforme (GBM) with the value obtained by magnetic resonance spectroscopy (MRS) and apparent diffusion coefficient (ADC) in the tumor and the tumor-adjacent area in magnetic resonance imaging (MRI).

Methods

A total of 38 patients were operated for GBM. All the patients had received diffusion-weighted imaging (DWI) and MRS prior to surgery. ADC of water molecules and values of metabolite indexes of MRS, including n-acetyl aspartate (NAA), choline (Cho) and creatine (Cr), were recorded, and the ratios of Cho/NAA, Cho/Cr and NAA/Cr were calculated. Hematoxylin-eosin (H&E) staining was done to examine the morphology of tumor and of tumor-adjacent tissues; immunohistochemistry (IHC) was performed to examine the expressions of PTEN and p53 in the tumor and the tumor-adjacent area. Finally, the correlations of the expressions of PTEN and p53 with ADC, Cho/NAA, Cho/Cr and NAA/Cr of the tumor and the tumor-adjacent area were analyzed.

Results

H&E staining showed that GBM tissues had disordered morphology, different sizes of cells, large cell nuclei and significant cell heterogeneity. IHC indicated that the expression level of p53 protein in the tumor was significantly higher than in the tumor-adjacent tissues (p<0.05). The expression level of PTEN protein was high in the tumor-adjacent tissues, but significantly deficient in the tumor. DWI showed that the signal of DWI in the tumor was significantly increased, but ADC was decreased compared with the tumor-adjacent area. MRS indicated that the wave band of Cho in the tumor was significantly increased, NAA was significantly lowered, and Cr section was decreased compared with the tumor-adjacent area, while NAA/Cr in the tumor was significantly decreased compared with the tumoradjacent area (p<0.05). Correlation analysis indicated that PTEN levels in the tumor and the tumor-adjacent area were positively correlated with ADC in the corresponding area, while p53 in the tumor and the tumor-adjacent area was negatively correlated with ADC in the corresponding area. Cho/NAA and Cho/Cr in the tumor were positively correlated with p53 in the tumor, but negatively correlated with PTEN in the tumor. However, NAA/Cr of the tumor was irrelevant to the levels of PTEN and p53.

Conclusions

The test results of DWI and MRS of patients with GBM can accurately reflect the inactivation or mutation of PTEN and p53."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/author"Jiang Y."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/author"Xu C."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/author"Zhao T."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/author"Ji F."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/date"2018"xsd:gYear
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http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/title"Correlation analysis of expressions of PTEN and p53 with the value obtained by magnetic resonance spectroscopy and apparent diffusion coefficient in the tumor and the tumor-adjacent area in magnetic resonance imaging for glioblastoma."xsd:string
http://purl.uniprot.org/citations/29745082http://purl.uniprot.org/core/volume"23"xsd:string
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