| http://purl.uniprot.org/citations/29746837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29746837 | http://www.w3.org/2000/01/rdf-schema#comment | "Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of immunocompetent small animal models, in part because ZIKV fails to effectively antagonize Stat2-dependent interferon (IFN) responses in mice. To address this limitation, we first passaged an African ZIKV strain (ZIKV-Dak-41525) through Rag1-/- mice to obtain a mouse-adapted virus (ZIKV-Dak-MA) that was more virulent than ZIKV-Dak-41525 in mice treated with an anti-Ifnar1 antibody. A G18R substitution in NS4B was the genetic basis for the increased replication, and resulted in decreased IFN-β production, diminished IFN-stimulated gene expression, and the greater brain infection observed with ZIKV-Dak-MA. To generate a fully immunocompetent mouse model of ZIKV infection, human STAT2 was introduced into the mouse Stat2 locus (hSTAT2 KI). Subcutaneous inoculation of pregnant hSTAT2 KI mice with ZIKV-Dak-MA resulted in spread to the placenta and fetal brain. An immunocompetent mouse model of ZIKV infection may prove valuable for evaluating countermeasures to limit disease."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2018.04.003"xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Best S.M."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Garcia-Sastre A."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Ye J."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Tripathi S."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Diamond M.S."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Ruckert C."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Young M.C."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Cao B."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "McNally K.L."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Baric R.S."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Artyomov M.N."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Robertson S.J."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Ebel G.D."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Morrison J."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Gorman M.J."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Uccellini M.B."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Mysorekar I.U."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Caine E.A."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Dinnon K.H."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Weger-Lucarelli J."xsd:string |
| http://purl.uniprot.org/citations/29746837 | http://purl.uniprot.org/core/author | "Yount B.L."xsd:string |