| http://purl.uniprot.org/citations/29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29748380 | http://www.w3.org/2000/01/rdf-schema#comment | "Hemidesmosomes are epithelial-specific attachment structures that maintain tissue integrity and resist tension. Despite their importance, how hemidesmosomes are regulated at the post-transcriptional level is poorly understood. Caenorhabditiselegans hemidesmosomes (CeHDs) have a similar structure and composition to their mammalian counterparts, making C. elegans an ideal model for studying hemidesmosomes. Here, we focus on the transcription regulator CCAR-1, identified in a previous genetic screen searching for enhancers of mutations in the conserved hemidesmosome component VAB-10A (known as plectin in mammals). Loss of CCAR-1 function in a vab-10(e698) background results in CeHD disruption and muscle detachment from the epidermis. CCAR-1 regulates CeHD biogenesis, not by controlling the transcription of CeHD-related genes, but by affecting the alternative splicing of unc-52 (known as perlecan or HSPG2 in mammals), the predicted basement extracellular matrix (ECM) ligand of CeHDs. CCAR-1 physically interacts with HRP-2 (hnRNPR in mammals), a splicing factor known to mediate unc-52 alternative splicing to control the proportions of different UNC-52 isoforms and stabilize CeHDs. Our discovery underlines the importance of post-transcriptional regulation in hemidesmosome reorganization. It also uncovers previously unappreciated roles of CCAR-1 in alternative splicing and hemidesmosome biogenesis, shedding new light on the mechanisms through which mammalian CCAR1 functions in tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.214379"xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Dong M."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Fu R."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Huang Z."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/author | "Labouesse M."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/pages | "jcs214379"xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/title | "CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis."xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/29748380 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29748380 |
| http://purl.uniprot.org/citations/29748380 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29748380 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUM4-mappedCitation-29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29748380 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AWB0-mappedCitation-29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29748380 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AWY7-mappedCitation-29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29748380 |
| http://purl.uniprot.org/uniprot/#_A0A061ACN9-mappedCitation-29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29748380 |
| http://purl.uniprot.org/uniprot/#_A0A061AE46-mappedCitation-29748380 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29748380 |