| http://purl.uniprot.org/citations/29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29752385 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial patterning in the developing Drosophila melanogaster eye requires the Neph1 homolog Roughest (Rst), an immunoglobulin family cell surface adhesion molecule expressed in interommatidial cells (IOCs). Here, using a novel temperature-sensitive (ts) allele, we show that the phosphoinositide phosphatase Sac1 is also required for IOC patterning. Sac1ts mutants have rough eyes and retinal patterning defects that resemble rst mutants. Sac1ts retinas exhibit elevated levels of phosphatidylinositol 4-phosphate (PI4P), consistent with the role of Sac1 as a PI4P phosphatase. Indeed, genetic rescue and interaction experiments reveal that restriction of PI4P levels by Sac1 is crucial for normal eye development. Rst is delivered to the cell surface in Sac1ts mutants. However, Sac1ts mutant IOCs exhibit severe defects in microtubule organization, associated with accumulation of Rst and the exocyst subunit Sec8 in enlarged intracellular vesicles upon cold fixation ex vivo Together, our data reveal a novel requirement for Sac1 in promoting microtubule stability and suggest that Rst trafficking occurs in a microtubule- and exocyst-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.151571"xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Burgess J."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Brill J.A."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Polevoy G."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Wei H.C."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Mayinger P."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Wilk R."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Price J.V."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Blagoveshchenskaya A."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Del Bel L.M."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/author | "Griffiths N."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/pages | "dev151571"xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/title | "The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye."xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://purl.uniprot.org/core/volume | "145"xsd:string |
| http://purl.uniprot.org/citations/29752385 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29752385 |
| http://purl.uniprot.org/citations/29752385 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29752385 |
| http://purl.uniprot.org/uniprot/#_A0A6F7SG83-mappedCitation-29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29752385 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EES5-mappedCitation-29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29752385 |
| http://purl.uniprot.org/uniprot/#_A1Z9X4-mappedCitation-29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29752385 |
| http://purl.uniprot.org/uniprot/#_O97174-mappedCitation-29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29752385 |
| http://purl.uniprot.org/uniprot/#_Q08180-mappedCitation-29752385 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29752385 |