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http://purl.uniprot.org/citations/29753316http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/29753316http://www.w3.org/2000/01/rdf-schema#comment"

Background

ZFX is a transcriptional regulator in embryonic stem cells and plays an important role in pluripotency and self-renewal. ZFX is widely expressed in pluripotent stem cells and is down-regulated during differentiation of embryonic stem cells. ZFX has five different variants that encode three different protein isoforms. While several reports have determined the overexpression of ZFX in a variety of somatic cancers, the expression of ZFX-spliced variants in cancer cells is not well-understood.

Methods

We investigated the expression of ZFX variants in a series of breast cancer tissues and cell lines using quantitative PCR.

Results

The expression of ZFX variant 1/3 was higher in tumor tissue compared to marginal tissue. In contrast, the ZFX variant 5 was down-regulated in tumor tissues. While the ZFX variant 1/3 and ZFX variant 5 expression significantly increased in low-grade tumors, ZFX variant 4 was strongly expressed in high-grade tumors, demonstrating lymphatic invasion. In addition, our result revealed a significant association between the HER2 status and the expression of ZFX-spliced variants.

Conclusion

Our data suggest that the expression of ZFX-spliced transcripts varies between different types of breast cancer and may contribute to their tumorigenesis process. Hence, ZFX-spliced transcripts could be considered as novel tumor markers with a probable value in diagnosis, prognosis, and therapy of breast cancer."xsd:string
http://purl.uniprot.org/citations/29753316http://purl.org/dc/terms/identifier"doi:10.29252/.23.1.47"xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/author"Farsinejad A."xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/author"Asadi M.H."xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/author"Pourkeramati F."xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/author"Shakeri"xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/date"2019"xsd:gYear
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/name"Iran Biomed J"xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/pages"47-56"xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/title"Differential Expression Profile of ZFX Variants Discriminates Breast Cancer Subtypes."xsd:string
http://purl.uniprot.org/citations/29753316http://purl.uniprot.org/core/volume"23"xsd:string
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