| http://purl.uniprot.org/citations/29755453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29755453 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) are major players for the induction of immune responses. Apart from plasmacytoid DCs (pDCs), human DCs can be categorized into two types of conventional DCs: CD141+ DCs (cDC1) and CD1c+ DCs (cDC2). Defining uniquely expressed surface markers on human immune cells is not only important for the identification of DC subpopulations but also a prerequisite for harnessing the DC subset-specific potential in immunomodulatory approaches, such as antibody-mediated antigen targeting. Although others identified CLEC9A as a specific endocytic receptor for CD141+ DCs, such a receptor for CD1c+ DCs has not been discovered, yet. By performing transcriptomic and flow cytometric analyses on human DC subpopulations from different lymphohematopoietic tissues, we identified CLEC10A (CD301, macrophage galactose-type C-type lectin) as a specific marker for human CD1c+ DCs. We further demonstrate that CLEC10A rapidly internalizes into human CD1c+ DCs upon binding of a monoclonal antibody directed against CLEC10A. The binding of a CLEC10A-specific bivalent ligand (the MUC-1 peptide glycosylated with N-acetylgalactosamine) is limited to CD1c+ DCs and enhances the cytokine secretion (namely TNFα, IL-8, and IL-10) induced by TLR 7/8 stimulation. Thus, CLEC10A represents not only a candidate to better define CD1c+ DCs-due to its high endocytic potential-CLEC10A also exhibits an interesting candidate receptor for future antigen-targeting approaches."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.00744"xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Hartmann A."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Dudziak D."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Nimmerjahn F."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Heger L."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Heidkamp G.F."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Lehmann C.H.K."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Garcia-Martin F."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Balk S."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Nishimura S.I."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Cesnjevar R."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Purbojo A."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Hatscher L."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/author | "Luhr J.J."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/pages | "744"xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/title | "CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion."xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29755453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29755453 |
| http://purl.uniprot.org/citations/29755453 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29755453 |
| http://purl.uniprot.org/uniprot/#_A8K7G0-mappedCitation-29755453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29755453 |
| http://purl.uniprot.org/uniprot/#_J3KR22-mappedCitation-29755453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29755453 |