| http://purl.uniprot.org/citations/29765039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29765039 | http://www.w3.org/2000/01/rdf-schema#comment | "Enriched PD-L1 expression in cancer stem-like cells (CSCs) contributes to CSC immune evasion. However, the mechanisms underlying PD-L1 enrichment in CSCs remain unclear. Here, we demonstrate that epithelial-mesenchymal transition (EMT) enriches PD-L1 in CSCs by the EMT/β-catenin/STT3/PD-L1 signaling axis, in which EMT transcriptionally induces N-glycosyltransferase STT3 through β-catenin, and subsequent STT3-dependent PD-L1 N-glycosylation stabilizes and upregulates PD-L1. The axis is also utilized by the general cancer cell population, but it has much more profound effect on CSCs as EMT induces more STT3 in CSCs than in non-CSCs. We further identify a non-canonical mesenchymal-epithelial transition (MET) activity of etoposide, which suppresses the EMT/β-catenin/STT3/PD-L1 axis through TOP2B degradation-dependent nuclear β-catenin reduction, leading to PD-L1 downregulation of CSCs and non-CSCs and sensitization of cancer cells to anti-Tim-3 therapy. Together, our results link MET to PD-L1 stabilization through glycosylation regulation and reveal it as a potential strategy to enhance cancer immunotherapy efficacy."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-018-04313-6"xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Chen Y.C."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Yu W.H."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Xia W."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Khoo K.H."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Cha J.H."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Chang S.S."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Chen C.T."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Li C.W."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Hsu J.M."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Liao H.W."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Hsu J.L."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Kuo C.W."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Hsu Y.H."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Lim S.O."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Chan L.C."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/author | "Ren G.X."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/pages | "1908"xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/title | "STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion."xsd:string |
| http://purl.uniprot.org/citations/29765039 | http://purl.uniprot.org/core/volume | "9"xsd:string |