| http://purl.uniprot.org/citations/29770132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29770132 | http://www.w3.org/2000/01/rdf-schema#comment | "gp130 cytokines are differentially involved in regulating the T helper (H) 17-driven pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of human multiple sclerosis. Interleukin (IL)-6 directly promotes the development of TH17 cells through the gp130/IL-6R complex. By contrast, IL-27 has been shown to suppress a TH17 immune response by gp130/IL-27R-alpha (α) receptor ligation. The IL-27-dependent regulation of a TH17 development could be mediated on the level of CD4 T cells. However, because IL-27 also suppresses the secretion of the TH17-driving cytokines IL-6 and IL-12/23p40 in accessory cells, TH17 immune responses may also be controlled by IL-27 on the level of macrophages and/or neutrophils. To analyze these opposing effects of gp130 engagement on the pathogenesis of EAE, we immunized CD4+ T cell-specific gp130-deficient (CD4creposgp130loxP/loxP) and macrophage/neutrophil-specific gp130-deficient (LysMcreposgp130loxP/loxP) mice with the myelin-oligodendrocyte-glycoprotein peptide MOG35-55. Whereas inflammatory immune responses, TH17 differentiation, and pathology in CD4creposgp130loxP/loxP mice were mitigated, disease progression was eventually enhanced in LysMcreposgp130loxP/loxP mice. Exacerbated disease in MOG35-55-immunized LysMcreposgp130loxP/loxP mice was associated with an elevated development of TH17 cells and increased infiltration of the central nervous system with leukocytes indicating a suppressive role of macrophage/neutrophil-gp130. To further prove IL-6 to be responsible for the control of inflammation during EAE through gp130 on macrophages/neutrophils, we immunized LysMcreposIL-6RloxP/loxP mice. In contrast to LysMcreposgp130loxP/loxP mice, neuropathology in MOG35-55-immunized macrophage/neutrophil-specific IL-6R-deficient mice was not enhanced indicating that the alleviation of EAE through macrophage/neutrophil-gp130 is mediated independently of IL-6. Together, this different pathology in macrophage/neutrophil- and CD4 T cell-specific gp130-deficient mice suggests that gp130 cytokines modulate TH17 inflammation differentially by targeting distinct cell types."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.00836"xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Deng F."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Rose-John S."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Prinz M."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Holscher C."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Holscher A."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Holz K."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Brendecke S.M."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/author | "Mitrucker H.W."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/pages | "836"xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/title | "Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice."xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29770132 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29770132 |
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