| http://purl.uniprot.org/citations/29771365 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29771365 | http://www.w3.org/2000/01/rdf-schema#comment | "Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding site consisting of two domains, RBS1 and RBS2, which differ in RNA-binding capacity and the ability to modulate translation. Here, we show that these domains recognize distinct RNA targets in living cells. Interestingly, the most abundant and exclusive RNA target of the RBS1 domain was Gemin5 mRNA. Biochemical and functional characterization of this target demonstrated that RBS1 polypeptide physically interacts with a predicted thermodynamically stable stem-loop upregulating mRNA translation, thereby counteracting the negative effect of Gemin5 protein on global protein synthesis. In support of this result, destabilization of the stem-loop impairs the stimulatory effect on translation. Moreover, RBS1 stimulates translation of the endogenous Gemin5 mRNA. Hence, although the RBS1 domain downregulates global translation, it positively enhances translation of RNA targets carrying thermodynamically stable secondary structure motifs. This mechanism allows fine-tuning the availability of Gemin5 to play its multiple roles in gene expression control."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gky361"xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/author | "Martinez-Salas E."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/author | "Francisco-Velilla R."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/author | "Fernandez-Chamorro J."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/author | "Dotu I."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/pages | "7339-7353"xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/title | "The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation."xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/29771365 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29771365 |
| http://purl.uniprot.org/citations/29771365 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29771365 |
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