| http://purl.uniprot.org/citations/29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29777784 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadherin switch is an initiating factor of epithelial-mesenchymal transition (EMT) and is intimately correlated with cancer metastatic potential; however, its underlying mechanisms remain unclear. Here, using a transforming growth factor-β (TGF-β)-induced EMT model, we provide explicit evidence that CD146, with elevated expression and activity in a variety of cancers, is a key factor involved in the cadherin switch. We show that CD146 can be induced by TGF-β signaling. Moreover, CD146 expression is positively correlated with the activation levels of STAT3/Twist and ERK pathways. Transcriptional response of the CD146/STAT3/Twist cascade inhibits E-cadherin expression, whereas the CD146/ERK cascade enhances N-cadherin expression. CD146 overexpression also significantly promotes EMT in both mouse embryonic fibroblasts (MEFs) and ovarian cancer cells. Clinically, ovarian cancer patients with detectable CD146 expression had a significantly lower survival rate than that of patients without CD146 expression. Furthermore, CD146-deficient MEFs exhibited decreased motility as a result of reversion in this cadherin switch, strongly suggesting that targeting CD146 is a potential strategy for cancer treatment. Therefore, CD146-mediated regulation of the E-cadherin-to-N-cadherin switch provides an insight into the general mechanisms of EMT as well as cancer metastasis."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2018.05.016"xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/author | "Xiong C."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/pages | "201-214"xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/title | "CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-beta signaling-induced epithelial-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://purl.uniprot.org/core/volume | "430"xsd:string |
| http://purl.uniprot.org/citations/29777784 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29777784 |
| http://purl.uniprot.org/citations/29777784 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29777784 |
| http://purl.uniprot.org/uniprot/#_A8K6A6-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |
| http://purl.uniprot.org/uniprot/#_B3KXZ9-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |
| http://purl.uniprot.org/uniprot/#_B2R642-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |
| http://purl.uniprot.org/uniprot/#_P43121-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |
| http://purl.uniprot.org/uniprot/#_Q9NQ41-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |
| http://purl.uniprot.org/uniprot/#_Q8R2Y2-mappedCitation-29777784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29777784 |