| http://purl.uniprot.org/citations/29784854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29784854 | http://www.w3.org/2000/01/rdf-schema#comment | "High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2; Trp53L/L; PtenL/L; Rosa26LSL-Luc (UPPL, luminal-like) and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely used MB49 cells. Following engraftment into immunocompetent C57BL/6 mice, BBN tumors were more responsive to PD-1 inhibition than UPPL tumors. Responding tumors within the BBN model showed differences in immune microenvironment composition, including increased ratios of CD8+:CD4+ and memory:regulatory T cells. Finally, we predicted and confirmed immunogenicity of tumor neoantigens in each model. These UPPL and BBN models will be a valuable resource for future studies examining bladder cancer biology and immunotherapy.Significance: This work establishes human-relevant mouse models of bladder cancer. Cancer Res; 78(14); 3954-68. ©2018 AACR."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-18-0173"xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Chai S."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Kardos J."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Saito R."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Kim W.Y."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Utsumi T."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Smith C.C."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Williams S.E."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Stewart K.G."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Vincent B.G."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Damrauer J.S."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Wobker S.E."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Byrd K.M."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Bixby L.M."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/author | "Manocha U."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/pages | "3954-3968"xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/title | "Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/29784854 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29784854 |
| http://purl.uniprot.org/citations/29784854 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29784854 |
| http://purl.uniprot.org/uniprot/#_A0A024QYR9-mappedCitation-29784854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29784854 |