| http://purl.uniprot.org/citations/29792861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29792861 | http://www.w3.org/2000/01/rdf-schema#comment | "Intensified oxidative stress can cause severe damage to human retinal pigment epithelium (RPE) cells and retinal ganglion cells (RGCs). The potential effect of neuroligin-3 (NLGN3) against the process is studied here. Our results show that NLGN3 efficiently inhibited hydrogen peroxide (H2O2)-induced death and apoptosis in human RPE cells and RGCs. H2O2-induced reactive oxygen species (ROS) production, lipid peroxidation and DNA damage in retinal cells were alleviated by NLGN3. NLGN3 activated nuclear-factor-E2-related factor 2 (Nrf2) signaling, enabling Nrf2 protein stabilization, nuclear translocation and expression of key anti-oxidant enzymes (HO1, NOQ1 and GCLC) in RPE cells and RGCs. Further results demonstrate that NLGN3 activated Akt-mTORC1 signaling in retinal cells. Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression. Significantly, Nrf2 silencing by targeted shRNAs reversed NLGN3-induced retinal cytoprotection against H2O2. We conclude that NLGN3 activates Nrf2 signaling to protect human retinal cells from H2O2. NLGN3 could be further tested as a valuable retinal protection agent."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.05.141"xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/author | "Li X.M."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/pages | "166-172"xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/title | "Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling."xsd:string |
| http://purl.uniprot.org/citations/29792861 | http://purl.uniprot.org/core/volume | "502"xsd:string |
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