| http://purl.uniprot.org/citations/29795111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29795111 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As obesity and diabetes become more prevalent, the contribution of non-alcoholic fatty liver disease (NAFLD) to HCC is rising. Recently, we reported intrahepatic CD4+ T cells are critical for anti-tumor surveillance in NAFLD. Lipid accumulation in the liver is the hallmark of NAFLD, which may perturb T cell function. We sought to investigate how the lipid-rich liver environment influences CD4+ T cells by focusing on carnitine palmitoyltransferase (CPT) family members, which control the mitochondrial β-oxidation of fatty acids and act as key molecules in lipid catabolism. Linoleic acid (C18:2) co-localized within the mitochondria along with a corresponding increase in CPT gene upregulation. This CPT upregulation can be recapitulated by feeding mice with a high-C18:2 diet or the NAFLD promoting methionine-choline-deficient (MCD) diet. Using an agonist and antagonist, the induction of CPT genes was found to be mediated by peroxisome proliferator-activated receptor alpha (PPAR-α). CPT gene upregulation increased mitochondrial reactive oxygen species (ROS) and led to cell apoptosis. In vivo, using liver-specific inducible MYC transgenic mice fed MCD diet, blocking CPT with the pharmacological inhibitor perhexiline decreased apoptosis of intrahepatic CD4+ T cells and inhibited HCC tumor formation. These results provide useful information for potentially targeting the CPT family to rescue intrahepatic CD4+ T cells and to aid immunotherapy for NAFLD-promoted HCC."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-018-0687-6"xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Fu Q."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Luo J."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Wilson A."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Kruhlak M."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Heinrich B."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Yu S.J."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Greten T.F."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Shi Z.D."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Brown Z.J."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/author | "Swenson R."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/pages | "620"xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/title | "Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development."xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29795111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29795111 |
| http://purl.uniprot.org/citations/29795111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29795111 |
| http://purl.uniprot.org/uniprot/#_A8ASF5-mappedCitation-29795111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29795111 |
| http://purl.uniprot.org/uniprot/#_A0A494BBF2-mappedCitation-29795111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29795111 |