| http://purl.uniprot.org/citations/29800590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29800590 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAccurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome.MethodsHLA genes expression analysis was initially performed using microarray data of 53 PIB, previously generated by our laboratory. The validation analysis was performed by real-time PCR in 116 PIB from an independent cohort.ResultsThe microarray data showed association between high expression levels of HLA class II genes, especially HLA-DQB1 and -DQB2, in kidneys from young (18 to 49-year-old) donors and poor (eGFR < 45 mL/min/1.73 m2) 1- and 5-year graft function. A subsequent study in an independent cohort, in which only HLA-DQB2 expression was evaluated, validated the association between increased HLA-DQB2 expression in PIB of kidneys from young donors and poor 1-year graft function: expression levels ≥0.0025 relative units conferred an odds ratio of 22.5, with positive and negative predictive values of 71.4% and 90.0%, respectively.ConclusionHeightened expression of HLA-DQB1 and -DQB2 in PIB are promising tools for pre-transplant risk assessment of poor late graft function in transplants with kidneys from 18 to 49-year-old donors."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2018.05.002"xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Gerbase-DeLima M."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Medina-Pestana J.O."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Mourao T.B."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Mine K.L."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Aguiar B."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Felipe C.R."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Tedesco-Silva H."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Campos E.F."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/author | "Salzedas L.A."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/pages | "594-601"xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/title | "Heightened expression of HLA-DQB1 and HLA-DQB2 in pre-implantation biopsies predicts poor late kidney graft function."xsd:string |
| http://purl.uniprot.org/citations/29800590 | http://purl.uniprot.org/core/volume | "79"xsd:string |
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