| http://purl.uniprot.org/citations/29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29804808 | http://www.w3.org/2000/01/rdf-schema#comment | "Normal epithelial tissue exerts an intrinsic tumor-suppressive effect against oncogenically transformed cells. In Drosophila imaginal epithelium, clones of oncogenic polarity-deficient cells mutant for scribble (scrib) or discs large (dlg) are eliminated by cell competition when surrounded by wild-type cells. Here, through a genetic screen in Drosophila, we identify Serpin5 (Spn5), a secreted negative regulator of Toll signaling, as a crucial factor for epithelial cells to eliminate scrib mutant clones from epithelium. Downregulation of Spn5 in wild-type cells leads to elevation of Toll signaling in neighboring scrib cells. Strikingly, forced activation of Toll signaling or Toll-related receptor (TRR) signaling in scrib clones transforms scrib cells from losers to supercompetitors, resulting in tumorous overgrowth of mutant clones. Mechanistically, Toll activation in scrib clones leads to c-Jun N-terminal kinase (JNK) activation and F-actin accumulation, which cause strong activation of the Hippo pathway effector Yorkie that blocks cell death and promotes cell proliferation. Our data suggest that Spn5 secreted from normal epithelial cells acts as a component of the extracellular surveillance system that facilitates elimination of pre-malignant cells from epithelium."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2018.04.022"xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/author | "Igaki T."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/author | "Ohsawa S."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/author | "Katsukawa M."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/pages | "1756-1767.e6"xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/title | "Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/29804808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29804808 |
| http://purl.uniprot.org/citations/29804808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHQ0-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHD4-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY4-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6M4-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6Q4-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_E1JHK1-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |
| http://purl.uniprot.org/uniprot/#_E1JHK2-mappedCitation-29804808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29804808 |