| http://purl.uniprot.org/citations/29807011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29807011 | http://www.w3.org/2000/01/rdf-schema#comment | "Tendinopathy is a common musculoskeletal disorder with characteristic hypervascularity. The mechanism of angiogenesis in tendinopathy remains unclear. The present study aimed to investigate the roles of miR-148a-3p in angiogenesis development of tendinopathy. In this study, we demonstrated that miR-148a-3p expression was increased in tendinopathy tissues and positively correlated with CD34 levels which is a specific marker for angiogenesis. We identified Krüppel-like factor 6 (KLF6) as a direct target gene of miR-148a-3p in tenocytes. Furthermore, reduced levels of KLF6 in tendinopathy tissues was showed using qRT-PCR and immunohistochemical analysis, compared with controls. A negative correlation between the levels of KLF6 mRNA and miR-148a-3p was observed. Then, we verified that miR-148a-3p could regulate Tsp-4 expression by targeting KLF6 in tenocyte and was positively correlated with Tsp-4 levels in tendinopathy tissues. In a coculture system of tenocytes with endothelial cells (ECs), we observed that transfection of Lv-miR-148a-3p markedly upregulated EC angiogenesis. In summary, our data establish a novel molecular mechanism by which miR-148a-3p upregulates Tsp-4 expression in tenocytes to promote EC angiogenesis by targeting KLF6, which could be helpful for the treatment of tendinopathy in the future."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.05.167"xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/author | "Cheng B."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/author | "Ge H."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/author | "Wu P."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/author | "Shrestha A."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/pages | "276-282"xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/title | "MicroRNA 148a-3p promotes Thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting Kruppel-like factor 6."xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://purl.uniprot.org/core/volume | "502"xsd:string |
| http://purl.uniprot.org/citations/29807011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29807011 |
| http://purl.uniprot.org/citations/29807011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29807011 |
| http://purl.uniprot.org/uniprot/#_B7Z832-mappedCitation-29807011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807011 |
| http://purl.uniprot.org/uniprot/#_E7ES19-mappedCitation-29807011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807011 |
| http://purl.uniprot.org/uniprot/#_P35443-mappedCitation-29807011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807011 |
| http://purl.uniprot.org/uniprot/P35443 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29807011 |
| http://purl.uniprot.org/uniprot/B7Z832 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29807011 |
| http://purl.uniprot.org/uniprot/E7ES19 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/29807011 |