| http://purl.uniprot.org/citations/29807053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29807053 | http://www.w3.org/2000/01/rdf-schema#comment | "Yin Yang 1 (YY1) is a multifunctional transcription factor that can activate or repress transcription depending on the promotor and/or the co-factors recruited. YY1 is phosphorylated in various signaling pathways and is critical for different biological functions including embryogenesis, apoptosis, proliferation, cell-cycle regulation and tumorigenesis. Here we report that YY1 is a substrate for c-Abl kinase phosphorylation at conserved residue Y254 in the spacer region. Pharmacological inhibition of c-Abl kinase by imatinib, nilotinib and GZD824, knock-down of c-Abl using siRNA, and the use of c-Abl kinase-dead drastically reduces tyrosine phosphorylation of YY1. Both radioactive and non-radioactive in vitro kinase assays, as well as co-immunoprecipitation in different cell lines, show that the target of c-Abl phosphorylation is tyrosine residue 254. c-Abl phosphorylation has little effect on YY1 DNA binding ability or cellular localization in asynchronous cells. However, functional studies reveal that c-Abl mediated phosphorylation of YY1 regulates YY1's transcriptional ability in vivo. In conclusion, we demonstrate the novel role of c-Abl kinase in regulation of YY1's transcriptional activity, linking YY1 regulation with c-Abl tyrosine kinase signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2018.05.014"xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/author | "Alexander K.E."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/author | "Hurt M.M."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/author | "Kassardjian A."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/author | "Rizkallah R."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/author | "Daraiseh S.I."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta Mol Cell Res"xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/pages | "1173-1186"xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/title | "c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/29807053 | http://purl.uniprot.org/core/volume | "1865"xsd:string |
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