| http://purl.uniprot.org/citations/29807221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29807221 | http://www.w3.org/2000/01/rdf-schema#comment | "Deposition of type I collage in ECM is an important property of various fibrotic diseases including breast cancer. The excessive expression of type I collagen contributes to the rigidity of cancer tissue and increases the mechanical stresses which facilitate metastasis and proliferation of cancer cells via the activation of TGF-β signaling pathway. The increased mechanical stresses also cause the compression of blood vessels and result in hypoperfusion and impaired drug delivery in cancer tissue. Additionally, type I collage functions as the ligand of α2β1-integrin and DDR1/2 receptors on the membrane of cancer cells to initiate signal transduction leading to metastasis. The expression of type I collage in cancer cells is previously shown to be inducible by TGF-β however the detailed mechanism by which the synthesis of type I collagen is regulated in breast cancer cells remains unclear. Herein, we report that MRTF-A, a co-activator of SRF, is important for the regulation of type I collagen gene COL1A1 in breast cancer cells. MRTF-A physically interacted with the promoter of COL1A1 to facilitate histone acetylation and RNA polymerase II recruitment. The RhoC-ROCK signaling pathway which controls the nuclear localization of MRTF-A regulated the transcription of COL1A1 in human breast cancer cells. TGF-β and Wnt signaling increased the expression of both MRTF-A and COL1A1. Furthermore, depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-β or Wnt signaling, indicating the importance of MRTF-A in the synthesis of type I collagen in breast cancer. Given the crucial roles of type I collagen in the formation of metastasis-prone and hypoperfusion microenvironment, MRTF-A would be a potential target for the development of anti-breast cancer activities."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2018.05.092"xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Ma W."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Wei Z."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Ou G."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Meng C."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Zhang T.C."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/author | "Luo X.G."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/pages | "718-728"xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/title | "MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/29807221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29807221 |
| http://purl.uniprot.org/citations/29807221 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29807221 |
| http://purl.uniprot.org/uniprot/#_B0QY84-mappedCitation-29807221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807221 |
| http://purl.uniprot.org/uniprot/#_A4FUJ8-mappedCitation-29807221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807221 |
| http://purl.uniprot.org/uniprot/#_L8E8L9-mappedCitation-29807221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807221 |
| http://purl.uniprot.org/uniprot/#_Q29R68-mappedCitation-29807221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29807221 |