| http://purl.uniprot.org/citations/29807982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29807982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29807982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/29807982 | http://www.w3.org/2000/01/rdf-schema#comment | "The ultimate step in the formation of thebaine, a pentacyclic opiate alkaloid readily converted to the narcotic analgesics codeine and morphine in the opium poppy, has long been presumed to be a spontaneous reaction. We have detected and purified a novel enzyme from opium poppy latex that is capable of the efficient formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated byproducts, which are preferentially produced by spontaneous allylic elimination. Remarkably, thebaine synthase (THS), a member of the pathogenesis-related 10 protein (PR10) superfamily, is encoded within a novel gene cluster in the opium poppy genome that also includes genes encoding the four biosynthetic enzymes immediately upstream. THS is a missing component that is crucial to the development of fermentation-based opiate production and dramatically improves thebaine yield in engineered yeast."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-018-0059-7"xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41589-018-0059-7"xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chang L."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chang L."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Facchini P.J."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Facchini P.J."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chen H.-Y."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Chen H.-Y."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Vidanes G.M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Vidanes G.M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Cottarel G."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Cottarel G."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Hagel J.M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Hagel J.M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Enquist-Newman M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Enquist-Newman M."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Colbeck J."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Colbeck J."xsd:string |
| http://purl.uniprot.org/citations/29807982 | http://purl.uniprot.org/core/author | "Estrada R."xsd:string |