| http://purl.uniprot.org/citations/29813079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29813079 | http://www.w3.org/2000/01/rdf-schema#comment | "LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements. Most human cells contain two SUN proteins, Sun1 and Sun2, and several KASH-proteins suggesting that multiple functionally distinct LINC complexes co-exist in the nuclear envelope. We show here, however, that while Sun1 and Sun2 in HeLa cells are each able to bind KASH-domains, Sun1 is more efficiently incorporated into LINC complexes under normal growth conditions. Furthermore, the balance of Sun1 and Sun2 incorporated into LINC complexes is cell type-specific and is correlated with SRF/Mkl1-dependent gene expression. In addition, we found that Sun1 has a LINC complex-independent role in transcriptional control, possibly by regulating the SRF/Mkl1 pathway. Together, these data reveal novel insights into the mechanisms of LINC complex regulation and demonstrate that Sun1 modulates gene expression independently of its incorporation into LINC complexes."xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0197621"xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/author | "Carroll C.W."xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/author | "May C.K."xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/pages | "e0197621"xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/title | "Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression."xsd:string |
| http://purl.uniprot.org/citations/29813079 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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