| http://purl.uniprot.org/citations/29851084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29851084 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling by the transforming growth factor-β (TGF-β) is an essential pathway regulating a variety of cellular events. TGF-β is produced as a latent protein complex and is required to be activated before activating the receptor. The mechanical force at the cell surface is believed to be a mechanism for latent TGF-β activation. Using β-actin null mouse embryonic fibroblasts as a model, in which actin cytoskeleton and cell-surface biophysical features are dramatically altered, we reveal increased TGF-β1 activation and the upregulation of TGF-β target genes. In β-actin null cells, we show evidence that the enhanced TGF-β signaling relies on the active utilization of latent TGF-β1 in the cell culture medium. TGF-β signaling activation contributes to the elevated reactive oxygen species production, which is likely mediated by the upregulation of Nox4. The previously observed myofibroblast phenotype of β-actin null cells is inhibited by TGF-β signaling inhibition, while the expression of actin cytoskeleton genes and angiogenic phenotype are not affected. Together, our study shows a scenario that the alteration of the actin cytoskeleton and the consequent changes in cellular biophysical features lead to changes in cell signaling process such as TGF-β activation, which in turn contributes to the enhanced myofibroblast phenotype."xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.26808"xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/author | "Percipalle P."xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/pages | "8884-8895"xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/title | "Elevated transforming growth factor beta signaling activation in beta-actin-knockout mouse embryonic fibroblasts enhances myofibroblast features."xsd:string |
| http://purl.uniprot.org/citations/29851084 | http://purl.uniprot.org/core/volume | "233"xsd:string |
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