| http://purl.uniprot.org/citations/29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29859188 | http://www.w3.org/2000/01/rdf-schema#comment | "The androgen receptor (AR) signaling pathway plays a vital role in the normal development and function of the male reproductive organs. Dysregulation of the androgen-AR signaling pathway has been linked to prostate cancer. Here, we demonstrate that tumor susceptibility gene 101 (TSG101) regulates AR expression level via the endosome/lysosome degradation pathway. In LNCaP cells, TSG101 overexpression recruits the AR to TSG101-containing cytoplasmic vesicles resulting in reduced AR protein level and AR transactivation activity downregulation. Immunofluorescence microscopy demonstrated that TSG101-decorated cytoplasmic vesicles are associated with late endosomes/lysosomes and the AR could be found within the Lamp2 positive TSG101 vesicles upon lysosomal protease inhibitor treatment. Furthermore, chloroquine or bafilomycin A1 treatment was able to restore TSG101-mediated AR expression reduction. Based on these data, we conclude that the interaction of the AR and TSG101 leads to AR recruitment to TSG101-containing cytoplasmic vesicles and induces AR-attenuated expression through the late endosome/lysosome degradation pathway."xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2018.05.203"xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/author | "Ouyang P."xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/author | "Chu P.H."xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/pages | "157-164"xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/title | "TSG101 interacts with the androgen receptor and attenuates its expression through the endosome/lysosome pathway."xsd:string |
| http://purl.uniprot.org/citations/29859188 | http://purl.uniprot.org/core/volume | "503"xsd:string |
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| http://purl.uniprot.org/uniprot/#_D2KF13-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_C0JKD5-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_A0A3G2C3P2-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_A0A6H0MAB3-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
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| http://purl.uniprot.org/uniprot/#_F1D8N5-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_G4VV16-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_P10275-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_Q86SI0-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |
| http://purl.uniprot.org/uniprot/#_Q13771-mappedCitation-29859188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29859188 |