| http://purl.uniprot.org/citations/29861391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29861391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29861391 | http://www.w3.org/2000/01/rdf-schema#comment | "Translation of mRNAs is tightly regulated and constantly surveyed for errors. Aberrant translation can trigger co-translational protein and RNA quality control processes, impairments of which cause neurodegeneration by still poorly understood mechanism(s). Here we show that quality control of translation of mitochondrial outer membrane (MOM)-localized mRNA intersects with the turnover of damaged mitochondria, both orchestrated by the mitochondrial kinase PINK1. Mitochondrial damage causes stalled translation of complex-I 30 kDa subunit (C-I30) mRNA on MOM, triggering the recruitment of co-translational quality control factors Pelo, ABCE1, and NOT4 to the ribosome/mRNA-ribonucleoprotein complex. Damage-induced ubiquitination of ABCE1 by NOT4 generates poly-ubiquitin signals that attract autophagy receptors to MOM to initiate mitophagy. In the Drosophila PINK1 model, these factors act synergistically to restore mitophagy and neuromuscular tissue integrity. Thus ribosome-associated co-translational quality control generates an early signal to trigger mitophagy. Our results have broad therapeutic implications for the understanding and treatment of neurodegenerative diseases."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2018.05.007"xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2018.05.007"xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Lim J."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Lim J."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Montgomery S."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Montgomery S."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Stankiewicz T."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Stankiewicz T."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Vartak R."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/author | "Vartak R."xsd:string |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29861391 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |