| http://purl.uniprot.org/citations/29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29867931 | http://www.w3.org/2000/01/rdf-schema#comment | "Air pollution associated with ozone exposure represents a major inducer of respiratory disease in man. In mice, a single ozone exposure causes lung injury with disruption of the respiratory barrier and inflammation. We investigated the role of interleukin-1 (IL-1)-associated cytokines upon a single ozone exposure (1 ppm for 1 h) using IL-1α-, IL-1β-, and IL-18-deficient mice or an anti-IL-1α neutralizing antibody underlying the rapid epithelial cell death. Here, we demonstrate the release of the alarmin IL-1α after ozone exposure and that the acute respiratory barrier injury and inflammation and airway hyperreactivity are IL-1α-dependent. IL-1α signaling via IL-1R1 depends on the adaptor protein myeloid differentiation factor-88 (MyD88). Importantly, epithelial cell signaling is critical, since deletion of MyD88 in lung type I alveolar epithelial cells reduced ozone-induced inflammation. In addition, intratracheal injection of recombinant rmIL-1α in MyD88acid mice led to reduction of inflammation in comparison with wild type mice treated with rmIL-1α. Therefore, a major part of inflammation is mediated by IL-1α signaling in epithelial cells. In conclusion, the alarmin IL-1α released upon ozone-induced tissue damage and inflammation is mediated by MyD88 signaling in epithelial cells. Therefore, IL-1α may represent a therapeutic target to attenuate ozone-induced lung inflammation and hyperreactivity."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2018.00916"xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Peter D."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Chung K.F."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Maillet I."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Ryffel B."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Quesniaux V."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Fauconnier L."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Wiegman C."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/author | "Michaudel C."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/pages | "916"xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/title | "Interleukin-1alpha Mediates Ozone-Induced Myeloid Differentiation Factor-88-Dependent Epithelial Tissue Injury and Inflammation."xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/29867931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29867931 |
| http://purl.uniprot.org/citations/29867931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29867931 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHL2-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI16-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |
| http://purl.uniprot.org/uniprot/#_B2RWZ5-mappedCitation-29867931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29867931 |