| http://purl.uniprot.org/citations/29871863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29871863 | http://www.w3.org/2000/01/rdf-schema#comment | "Activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive lymphoproliferative disorder involving chronic NF-κB activation. Several mutations in the BCR and MyD88 signaling pathway components, such as MyD88 L265P, are implicated in this aberrant activation. Among heat shock proteins, HSP110 has recently been identified as a prosurvival and/or proliferation factor in many cancers, but its role in ABC-DLBCL survival mechanisms remained to be established. We observed that short hairpin RNA-mediated HSP110 silencing decreased the survival of several ABC-DLBCL cell lines and decreased immunoglobulin M-MyD88 co-localization and subsequent NF-κB signaling. Conversely, overexpression of HSP110 in ABC-DLBCL or non-DLBCL cell lines increased NF-κB signaling, indicating a tight interplay between HSP110 and the NF-κB pathway. By using immunoprecipitation and proximity ligation assays, we identified an interaction between HSP110 and both wild-type MyD88 and MyD88 L265P. HSP110 stabilized both MyD88 forms with a stronger effect on MyD88 L265P, thus facilitating chronic NF-κB activation. Finally, HSP110 expression was higher in lymph node biopsies from patients with ABC-DLBCL than in normal reactive lymph nodes, and a strong correlation was found between the level of HSP110 and MyD88. In conclusion, we identified HSP110 as a regulator of NF-κB signaling through MyD88 stabilization in ABC-DLBCL. This finding reveals HSP110 as a new potential therapeutic target in ABC-DLBCL."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2017-12-819706"xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Martin L."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Garrido C."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Verhoeyen E."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Weber A.N.R."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Wolz O.O."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Jego G."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Fest T."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Pangault C."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Jardin F."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Chassagne-Clement C."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Boudesco C."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Ramla S."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Mhaidly R."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/author | "Salmi L."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/pages | "510-520"xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/title | "HSP110 sustains chronic NF-kappaB signaling in activated B-cell diffuse large B-cell lymphoma through MyD88 stabilization."xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/29871863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29871863 |
| http://purl.uniprot.org/citations/29871863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29871863 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MSM0-mappedCitation-29871863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871863 |