| http://purl.uniprot.org/citations/29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/29871931 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-like EMT inducer (ILEI, FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell-biological process that confers metastatic properties to a tumor cell. However, very little is known about how ILEI is regulated. Here we demonstrate that ILEI is an in vivo regulator of melanoma invasiveness and is transcriptionally up-regulated by the upstream stimulatory factor-1 (USF-1), an E-box-binding, basic-helix-loop-helix family transcription factor. shRNA-mediated knockdown of ILEI in melanoma cell lines attenuated lung colonization but not primary tumor formation. We also identified the mechanism underlying ILEI transcriptional regulation, which was through a direct interaction of USF-1 with the ILEI promoter. Of note, stimulation of endogenous USF-1 by UV-mediated activation increased ILEI expression, whereas shRNA-mediated USF-1 knockdown decreased ILEI gene transcription. Finally, we report that knocking down USF-1 decreases tumor cell migration. In summary, our work reveals that ILEI contributes to melanoma cell invasiveness in vivo without affecting primary tumor growth and is transcriptionally up-regulated by USF-1."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.ra118.003616"xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Noguchi K."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Howe P.H."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Mohanty B.K."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Howley B.V."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Dincman T.A."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "Dalton A.C."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/author | "McCall B.J."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/pages | "11401-11414"xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/title | "Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1)."xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://purl.uniprot.org/core/volume | "293"xsd:string |
| http://purl.uniprot.org/citations/29871931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/29871931 |
| http://purl.uniprot.org/citations/29871931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/29871931 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4U5-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_E0CYP7-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_E9PJ52-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_E9Q6F0-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_E9Q722-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R2-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R4-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |
| http://purl.uniprot.org/uniprot/#_A0A7H1D2R5-mappedCitation-29871931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/29871931 |